Specialization


 * focus on a Specialization to gain increased (damage) bonuses
 * Choosing a  (Training Desk) is free
 * select a 1st specialization at level 15
 * select a 2nd specialization at level 30
 * certain Skills can reach skill 220
 * You can remove each Focused Specialization individually at the cost of 1000 caps

Assassin

 * Requires: Sneak 3 + Ninja 2
 * Grants +50 Stealth Skill
 * +10% Critical Hit Chance to melee weapons
 * +100% sneak attack damage to melee weapons
 * Reduces your VATS melee range
 * cancels any effects from the Blitz perk

NOTE: You can technically use this spec for ranged stealth improvements, but it's somewhat overkill, since ranged stealth detection is already much easier as it is. (This spec may need some testing/tuning for how well the sneaking works with non-vats melee)

Beast Master

 * Requires: Animal Friend 3
 * 2 animal companions max
 * +5 base damage (Animals)
 * -75% Weapon/Explosive damage taken (Animals)

Canine Handler

 * Requires: Attack Dog 3
 * 2 canine companions max
 * +5 base damage (Dogs)
 * -75% Weapon/Explosive damage taken (Dogs)

Combat Engineer

 * Requires: Robotics Expert 4
 * 3 devices max
 * +3 base damage (Turrets)
 * -75% Weapon/Explosive damage taken (Turrets)

Cyborg
You Were Born to Wield Energy Weapons


 * Requires: Future Soldier 3
 * +20% damage to (standard) Energy Weapons: (Gatling Laser, Cryolator, Gauss Rifles)
 * (does not include sniper, incendiary, or explosive weapons)
 * (does not include Energy Musket or Railgun)

Demolitionist

 * Requires: Demolition Expert 3
 * +25% damage to Incendiary Weapons: Explosives, Missile Launcher, Flamer, Fat Man

Duelist
Master of Pistols and Semi-Automatic Shotguns


 * Requires: Gunslinger 3
 * +20% damage to: Non-automatic Ballistic Pistols and Shotguns
 * +stagger chance

Marauder
Unmatched in Melee Combat

Note: Super Mutants and larger creatures can not be be knocked down by this ability
 * Requires: Big Leagues 3
 * +15% Critical Hit Chance to melee weapons
 * +20% damage (melee weapon, unarmed)
 * -15% melee damage taken
 * Power attacking with Blunt weapons have a +50% chance (Power Attack) to knock down opponents using (Blunt/Bladed weapons)
 * Power attacking with Bladed weapons have a +50% chance to cause opponents to bleed

Master Commando
Expert with Automatic Assault Weapons

Tip for Throwing Knives: They land low and to the left. If you play without crosshairs, you can aim with your weapon sight to line up your throw. Once you have the stagger perk, they work decently against a blocking opponent in a melee fight.
 * Requires: Commando 3
 * +5% Critical Hit Chance to all weapons
 * +20% Critical Hit Chance to Combat Knives and Throwing Knives
 * +10% damage to all automatic weapons (only when in automatic firing mode)
 * automatic weapons: Submachine Gun, Light Machine Gun, Minigun, Combat Rifle, Combat Shotgun

Ranger
Storm the Enemy Using Standard Ballistic Rifles


 * Requires: Trooper 3
 * +10% Critical Hit Chance for Standard Ballistic Rifles
 * Standard Ballistic Rifles: Combat Rifles, Pipe Rifles, LMG, SMG, etc. (may also include other similar weapons)
 * does not cover Shotguns, Pistols, or Sniper Weaponry

Sharpshooter
Skilled Precision with Sniper Weaponry


 * Requires: Sniper 3
 * +20% damage for Sniper Weapon (does not include standard rifles)
 * Sniper Weapon: Hunting Rifle, Combat Rifle, Pipe Rifles, Gauss Rifle, Railway Rifle

Vanguard

 * Requires: Iron Defender 3
 * -15% damage taken
 * -15% Limb damage taken
 * -15% Falling damage taken
 * -15% Damage dealt
 * Incoming staggering is reduced